Satraplatin (Synonyms: 沙铂; BMS182751; BMY45594; JM216)

目录号: HY-17576 纯度: 99.79%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

Satraplatin 是一种烷化剂 (alkylator)，具有抗肿瘤效果。

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Satraplatin Chemical Structure

CAS No. : 129580-63-8

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规格	价格	是否有货
1 mg	￥1150	In-stock
5 mg	￥2800	In-stock
10 mg	￥4000	In-stock
50 mg	现货	询价
100 mg		询价
200 mg		询价

or 大包装询价

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生物活性
实验参考方法
纯度 & 产品资料
参考文献

生物活性

Satraplatin is an alkylating agent, with potent antitumor effect.

体外研究
(In Vitro)

Satraplatin needs to avoid light in the solution, and it is unstable in the alkaline state but stable in the acidic state.
Satraplatin has potent antitumor activity. Satraplatin combined with dichloroacetate (DCA) inhibits UMC-11 cells with an IC₅₀ of 1.36 ± 0.11 μM^[1]. Satraplatin also suppresses CDDP-resistant (KB-R) cells (IC₅₀, 7.04 μM), and causes G2/M arrest in KB-R cells^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

500.28

Formula

C₁₀H₂₂Cl₂N₂O₄Pt

CAS 号

129580-63-8

性状

固体

颜色

Off-white to yellow

中文名称

赛特铂；沙铂

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

溶解性数据

细胞实验：

DMF 中的溶解度 : 10 mg/mL (19.99 mM; 超声助溶; 酸性条件溶解 (HCL 调节，pH≈1); DMSO can inactivate Satraplatin's activity)

H₂O 中的溶解度 : < 0.1 mg/mL (insoluble; DMSO can inactivate Satraplatin's activity)

Ethanol 中的溶解度 : < 1 mg/mL (insoluble; DMSO can inactivate Satraplatin's activity)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.9989 mL	9.9944 mL	19.9888 mL
5 mM	0.3998 mL	1.9989 mL	3.9978 mL
10 mM	0.1999 mL	0.9994 mL	1.9989 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.79%

选择批次：

Data Sheet (601 KB) SDS (393 KB)

COA (290 KB) LCMS (96 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Fiebiger W, et al. In vitro cytotoxicity of novel platinum-based drugs and dichloroacetate against lung carcinoid cell lines. Clin Transl Oncol. 2011 Jan;13(1):43-9. [Content Brief]

[2]. Yamano Y, et al. Antitumor activity of satraplatin in cisplatin-resistant oral squamous cell carcinoma cells. Head Neck. 2011 Mar;33(3):309-17. [Content Brief]

Cell Assay ^[1]	Cells are harvested, counted and distributed to microtiter plates in 100 μL medium at a density of 1×10⁴ cells/well. Appropriate dilutions of test compounds (Satraplatin, etc.) are added to a total volume of 200 μL/well and plates incubated under tissue culture conditions for four days. Stock solutions of the compounds are prepared in either 70% ethanol or DMSO and diluted more than 100-fold for the assays. Solvent controls are included in all tests. Dose response curves are obtained by assessing cell proliferation at twofold drug dilutions in triplicate and used for calculation of IC₅₀ values. Cell growth is quantified using a modified tetrazolium dye assay (MTT) and by measurement of the reduced formazane dye at 450 nm wavelength (medium control set to 100% proliferation)^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Fiebiger W, et al. In vitro cytotoxicity of novel platinum-based drugs and dichloroacetate against lung carcinoid cell lines. Clin Transl Oncol. 2011 Jan;13(1):43-9. [Content Brief] [2]. Yamano Y, et al. Antitumor activity of satraplatin in cisplatin-resistant oral squamous cell carcinoma cells. Head Neck. 2011 Mar;33(3):309-17. [Content Brief]

Cell Assay
^[1]

Cells are harvested, counted and distributed to microtiter plates in 100 μL medium at a density of 1×10⁴ cells/well. Appropriate dilutions of test compounds (Satraplatin, etc.) are added to a total volume of 200 μL/well and plates incubated under tissue culture conditions for four days. Stock solutions of the compounds are prepared in either 70% ethanol or DMSO and diluted more than 100-fold for the assays. Solvent controls are included in all tests. Dose response curves are obtained by assessing cell proliferation at twofold drug dilutions in triplicate and used for calculation of IC₅₀ values. Cell growth is quantified using a modified tetrazolium dye assay (MTT) and by measurement of the reduced formazane dye at 450 nm wavelength (medium control set to 100% proliferation)^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Fiebiger W, et al. In vitro cytotoxicity of novel platinum-based drugs and dichloroacetate against lung carcinoid cell lines. Clin Transl Oncol. 2011 Jan;13(1):43-9. [Content Brief]

[2]. Yamano Y, et al. Antitumor activity of satraplatin in cisplatin-resistant oral squamous cell carcinoma cells. Head Neck. 2011 Mar;33(3):309-17. [Content Brief]

Satraplatin 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMF	1 mM	1.9989 mL	9.9944 mL	19.9888 mL	49.9720 mL
	5 mM	0.3998 mL	1.9989 mL	3.9978 mL	9.9944 mL
	10 mM	0.1999 mL	0.9994 mL	1.9989 mL	4.9972 mL
	15 mM	0.1333 mL	0.6663 mL	1.3326 mL	3.3315 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Satraplatin129580-63-8BMS182751 BMY45594 JM216赛特铂沙铂BMS 182751BMS-182751BMY45594BMY 45594BMY-45594JM216JM 216JM-216DNA Alkylator/CrosslinkerInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Satraplatin (Synonyms: 沙铂; BMS182751; BMY45594; JM216)